With the peptide drugs more and more widely usage in the treatment of disease, researchers are not satisfied with requests of simple molecular chains in-depth increasing scientific research. In recent years,people began to try to bring the seven main group F, Cl and other halogen elements (fmk, modified CMK) into in peptide molecules. It was found that modification of these elements greatly changed the peptide molecular biological characteristics, greatly promoted the development of protein and peptide drugs.
Successful case:
Z-VAE(OMe)-FMK is a kind of cell permeable, irreversible pan caspase inhibitor, which can effectively restrain the process of cell apoptosis.
Z-VAE(OMe)-FMK，Molecular Weight：481.49，FMK modified
HPLC analysis:
MS analysis：
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